I'm playing Europa Universalis IV: Conquest of Paradise, an expansion for the real-time grand strategy game by Paradox Interactive.
The expansion comes with three main features. First, a plausibly randomized North and South America is available if you start your game before 1492. In addition, new Native American buildings and available for minor advances and bonuses that give these nations something to do with limited budgets. Also, single province Natives can migrate away from pesky Europeans and towards more profitable regions. Finally, five or more adjacent colonies will create a colonial nation that works much like a vassal: you can declare war on Native Americans, conduct diplomacy with other colonial nations, and break free from the motherland. If you spend a lot of time focusing on the New World, the features of Conquest of Paradise are a worthwhile expansion to Europa Universalis IV.